Hallmarks of Aging and Their Interactions
Date: Tuesday, November 12th
Time: 8:00 AM - 5:00 PM
Location: Sheraton - Metropolitan Ballroom A
The workshop is open to all attendees at the GSA 2024 annual meeting free of charge. Registration is required.
Aging, a complex process involving many cellular changes, is largely viewed as the biological deterioration and functional decline affecting all organisms including human. Breakthrough findings in recent decades have identified molecular and cellular pathways that can alter the course of lifespan and healthspan when manipulated in experimental model systems. These advances had laid the foundation for the proposed framework of hallmarks of aging capturing major molecular and cellular processes that contribute to aging and importantly, specify a mechanistic qualification where amelioration of the proposed hallmarks is expected to extend the healthspan of the organism. However, recent discoveries demonstrating that “fixing” one hallmark at a time may not significantly alter the aging process suggest that interventions could be more effectively devised through understanding the inter-play among the aging hallmarks.
In 2023, NIA issued three inter-connected RFAs and funded 26 projects: (1) Inter-Organelle Communication as a Platform to Interrogate the Interactions of Hallmarks of Aging (RFA-AG-23-012); (2) Mapping Interconnectivity Among Hallmarks of Aging under Lifespan Modifications (RFA-AG-23-013); (3) Studies of Cytosolic DNAs in the Interactions of Aging Hallmarks (RFA-AG-23-015).
This workshop aims to gather the awardees funded through these three RFAs to present their research findings to date. This workshop will be the inaugural meeting of the Aging Hallmarks Consortium, consisted of grantees of the three RFAs with regular meetings of PIs and key personnel, along with investigators working on these topics but funded independently of these RFAs.
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